Gaussian multiplication for resolution enhancement

When processing NMR data a window function, or apodisation, is typically applied to emphasise or deemphasise certain aspects of the spectrum. Numerous window functions are available each with their own benefits and drawbacks. A gaussian multiplication is often applied to 1D data to increase resolution at the expense of sensitivity.

Measuring pKa

A compound's pKa is a fundamental parameter that influences its solubility, membrane permeability, and protein binding and thus its ADME properties. Knowing the pKa of a compound can help with rational design and formulation. Because of its importance the FDA now requires new drug applications to report the compound's pKa. NMR is one of the ways to measure pKas and in this post I'll describe how its done.