Monday, October 5, 2020

COSY experiments

The COSY experiment was one of the very first 2D NMR experiments developed and still remains an essential tool. The original experiment has several shortcomings, however, and numerous modifications have been proposed. Three of the most useful are the gCOSY, the DQF-COSY, and the CLIP-COSY. This post discusses the problems of the original experiment and how the new versions attempt to solve them.