Monday, August 1, 2016

Sensitivity in HMBC and LR-HSQMBC experiments

Long range correlations are critical for structure elucidation. They are typically identified using HMBC experiments1, but a relatively recent alternative is the LR-HSQMBC experiment2. Recent attempts to confirm the structure of several challenging molecules in the Facility prompted an examination of the sensitivity of these two experiments to determine which is most likely to provide the crucial long range correlations.